Substance P affects the GABAergic system in the hypothalamo-pituitary axis |
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Authors: | Sandra Afione Luciano Debeljuk Adriana Seilicovich Daniel Pisera Mercedes Lasaga María del Carmen Díaz Beatriz Duvilanski |
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Institution: | Centro de Investigaciones en Reproducción, Facultad de Medicina Universidad de Buenos Aires, Argentina |
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Abstract: | In the present work we examined the effect of the neutralization of endogenous substance P by the administration of an anti-substance P serum (ASPS) on GABA concentration in the anterior pituitary in hyperprolactinemic conditions induced by 5-hydroxytryptophan or by grafting anterior pituitaries. ASPS reduced the increase in the anterior pituitary GABA concentration induced by hyperprolactinemia. In vitro experiments showed that substance P inhibited K+-evoked GABA efflux from hypothalamic fragments and decreased GABA concentration in the anterior pituitary but ASPS increased it. Our results demonstrate that substance P modifies hypothalamic GABA release and anterior pituitary GABA concentration and suggest that an interaction exists between substance P and GABA. |
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Keywords: | Substance P GABA Prolactin Anterior pituitary Hypothalamic fragments Anti-substance P serum |
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