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Disruption of the gene C12orf35 leads to increased productivities in recombinant CHO cell lines |
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| Authors: | Anett Ritter Tatjana Rauschert Mevion Oertli Daniel Piehlmaier Panagiotis Mantas Genevieve Kuntzelmann Nadine Lageyre Barbara Brannetti Bernd Voedisch Sabine Geisse Thomas Jostock Holger Laux |
| Institution: | 1. +41‐61‐6963312+41‐61‐6963373;2. Novartis Institutes for BioMedical Research, Basel, Switzerland;3. Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach CH‐4002, Basel, Switzerland;4. Novartis Pharma AG, Cell and Gene Therapies, Basel, Switzerland;5. +41‐61‐6963511+41‐61‐6963373 |
| Abstract: | |
| Keywords: | Chinese hamster ovary cells recombinant gene expression productivity cell line engineering chromosomal deletion mRNA |