Inhibitory activity of palladium(II) and platinum(II) complexes with isoxazole and its derivatives |
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Authors: | IA Zakharova JaV Salyn LV Tatjanenko YuSh Mashkovsky G Ponticelli |
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Institution: | Institute of General and Inorganic Chemistry, USSR Academy of Science, Moscow U.S.S.R.;Research Institute for Biological Tests of Chemical Compounds, Kupavna, Moscow U.S.S.R.;Istituto Chimico Policattedra, University of Cagliari U.S.S.R. |
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Abstract: | The investigation of the inhibitory activity on the membrane bonded ATP-ase of the M(L)2X2 complexes where M = Pd(II), Pt(II); L = isoxazole(isox), 3,5-dimethylisoxazole(3,5-diMeisox), 3-methyl,5-phenylisoxazole(3-Me,5-Phisox), 3,5-diphenylisoxazole-(3,5-diPhisox), and 4-amino-3,5-dimethylisoxazole(4-ADI); X = Cl, Br] is reported. These results show that the complexes with isox and its methyl and phenyl derivatives have a much stronger inhibitory effect than the corresponding free ligands; in the 4-ADI compounds this activity drops. The Pd(II) complexes have a greater effect than the Pt(II) derivatives. The interaction occurs with SH groups and probably also with other active centers of the enzyme. These conclusions have been correlated with the E.S.C.A. spectra. These measurements show that the electron density of the complexes on the central metal ion and Nring atom or Nring and N-hexocyclic atoms on passing from chloride to bromide derivatives changes slightly. |
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Keywords: | Address reprint requests to: G Ponticelli Instituto Chimico Policattedra University of Cagliari Cagliari Italy 09100 |
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