Regulating the activity of a cardioacceleratory peptide |
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Authors: | Nichols R Kaminski S Walling E Zornik E |
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Institution: | Department of Biological Chemistry, University of Michigan, Ann Arbor 48109-1048, USA. nicholsr@umich.edu |
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Abstract: | We measured the effect of crustacean cardioactive peptide on Drosophila heart rate in the animal and in a tissue preparation. Crustacean cardioactive peptide increased in vivo basal heart rate 1%, 6%, and 19% and increased in vitro basal heart rate 52%, 25%, and 35% in larvae, pupae, and adults, respectively. In the tissue preparation, the acceleratory period was followed by decreased in vitro heart rates of 42%, 16%, and 13% in larvae, pupae, and adults, respectively. The effects observed in the animal and tissue and in larvae, pupae, and adults suggest that Drosophila crustacean cardioactive peptide cardiac signaling is modulated and developmentally regulated. |
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