| 禽流感H5N1病毒感染BALB/c小鼠的细胞免疫动态变化 |
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| 引用本文： | 王颖彦,刘忠华,张钰,赵维波,吴琼,李文德,闵凡贵,刘香梅,黄韧. 禽流感H5N1病毒感染BALB/c小鼠的细胞免疫动态变化[J]. 中国实验动物学报, 2005, 0(Z1) |
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| 作者姓名： | 王颖彦 刘忠华 张钰 赵维波 吴琼 李文德 闵凡贵 刘香梅 黄韧 |
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| 作者单位： | 广州中医药大学第二附院 广州510120(王颖彦),广东省实验动物监测所 广州510260(刘忠华,张钰,赵维波,吴琼,李文德,闵凡贵,刘香梅),广东省实验动物监测所 广州510260(黄韧) |
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| 摘 要： | [目的]测定H5N1病毒感染BALB/c的小鼠模型的细胞免疫动态变化,探讨病毒对机体免疫系统的影响。[方法]通过流式细胞仪测定CD3+T、CD4+T、CD8+T等细胞免疫变化。[结果]感染H5N1病毒的小鼠血液中CD3+T、CD4+T、CD8+T细胞数量下降(P<0.05),脾脏中T细胞数量下降的趋势与血液相同,CD4+T/CD8+T的比例上升,只是两者的时间有所差别。[结论]说明病毒对细胞免疫T细胞数量影响较大,而且CD8+T受到的影响更为明显,反应了机体特异性细胞免疫功能受抑制,并且彼此之间的平衡受到破坏。
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| 关 键 词： | 禽流感H5N1病毒 T细胞 细胞免疫 免疫机制 |
Changes of the Immune Cell in the BALB/c Mice Infected with Avian Influenza H5N1 Viruses |
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| Yingyan Wang,Zhonghua Liu,Yu Zhang,Weibo Zhao,Wende Li,Fangui Min,Xiangmei Liu Ren Huang .Second Affiliated Hospital of Guangzhou University of TCM,Guangzhou ,.Guandong Laboratory Aminals Monitoring Institute,Guangzhou. Changes of the Immune Cell in the BALB/c Mice Infected with Avian Influenza H5N1 Viruses[J]. Acta Laboratorium Animalis Scientia Sinica, 2005, 0(Z1) |
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| Authors: | Yingyan Wang Zhonghua Liu Yu Zhang Weibo Zhao Wende Li Fangui Min Xiangmei Liu Ren Huang .Second Affiliated Hospital of Guangzhou University of TCM Guangzhou .Guandong Laboratory Aminals Monitoring Institute Guangzhou |
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| Affiliation: | Yingyan Wang1,Zhonghua Liu2,Yu Zhang2,Weibo Zhao2,Wende Li2,Fangui Min2,Xiangmei Liu2 Ren Huang2 1.Second Affiliated Hospital of Guangzhou University of TCM,Guangzhou 510120,2.Guandong Laboratory Aminals Monitoring Institute,Guangzhou 510260 |
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| Abstract: | [Objective] To analyze the pathogenic mechanism of avian influenza A (H5N1) viruses in mice by investigating the changes of the immune system. [Methods] To investigate CD3+T cells, CD4+T cells, CD8+T cells by the flow cytometry. [Result] Avian influenza A(H5N1) virus destroyed the immune system, CD3+T cells, CD4+T cells, CD8+T cells declined, while the ratio of CD4+T cells/CD8+T increased, the tendency was same in blood as well as in spleen. [Conclusion] Avian influenza A(H5N1) virus can inhibit cell immunity; especially the CD8+T. |
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| Keywords: | Avian influenza H5N1 viruses T cell Cell immunty immunologic mechanism |
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