Creatine phosphokinase activity in dysgenic (mdg/mdg) mouse muscle |
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Authors: | Francine B Essien Cheryl L Biber |
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Institution: | 1. Department of Biological Sciences, Douglass Campus, Rutgers University, New Brunswick, N.J.
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Abstract: | The specific activity of creatine phosphokinase (CPK) was measured in the muscle of mdg/mdg and control embryos of 14-18 days' gestation. CPK specific activity values were similar in mutant and normal embryos at the earliest stages examined (14-15 days). However, after 15 1/2 days, the specific activity of the enzyme in the mdg/mdg embryos was approximately 50% lower than in the controls. The dysgenic and normal muscle extracts exhibited comparable stability after storage at -85 C. CPK activity levels in the muscle of adult heterozygotes (+/mdg) and wild-type (+/+) controls were found to be statistically identical. The findings suggest that the mdg mutation does not have a primary or direct effect on CPK activity. |
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