Severely damaged kidneys possess multipotent renoprotective stem cells |
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| Authors: | Yousof Gheisari Seyed Mahdi Nassiri Ehsan Arefian Naser Ahmadbeigi Kayhan Azadmanesh Mansour Jamali Issa Jahanzad Sirous Zeinali Mohammad Vasei Masoud Soleimani |
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| Affiliation: | 1. Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA;2. Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran;3. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran;5. Drexel University College of Medicine, Philadelphia, PA, USA;6. Department of Medical Genetics and Molecular Biology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;7. Pediatric Urology Research Center, Department of Urology, Children''s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran;8. Viapath, St Thomas'' Hospital, London, UK;9. Department of Medical and Molecular Genetics, St. John''s Institute of Dermatology, King''s College London (Guy''s Campus), London, UK;10. Computational Medicine Center, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA;11. Kariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran;12. Department of Molecular Medicine, Sapienza University, Rome, Italy;13. Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA, USA |
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| Abstract: | Background aimsTissue-specific stem cells are a promising target for kidney regeneration, because it has been shown that they play a primary role in kidney repair. Several methods have been developed for the isolation of stem/progenitor cells from healthy kidneys but the existence of these cells in chronically damaged kidneys has not been noticed so far.MethodsA mouse model of chronic kidney failure was developed by ligation of the left ureter for 5 months, and then isolation of stem cells from this tissue as well as normal kidneys was attempted.ResultsWe found that multipotent stem cells could be isolated from both types of tissue. In addition, the cells isolated from damaged kidneys showed potential for homing to the site of injury and a renoprotective effect in an animal model of cisplatin-induced nephropathy.ConclusionsThese results show that multipotent renoprotective stem cells exist in severely damaged kidneys, which could be a target for designing new therapies. |
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