Antagonism between olive oil phenolics and nitric oxide on lymphomonocyte cytosolic calcium |
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| Authors: | Carlo A Palmerini Enrico Carlini Carla Saccardi Maurizio Servili Gianfrancesco Montedoro Giuseppe Arienti |
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| Institution: | (1) Dipartimento di Medicina Interna, Università di Perugia, Via del Giochetto, 06127 Perugia, Italy;(2) Dipartimento di Scienza degli Alimenti, S. Costanzo, Università di Perugia, 06100 Perugia, Italy |
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| Abstract: | Some biological actions of olive oil phenolics (inhibition of platelet aggregation, decrease of LDL-oxidation, inhibition
of bacterial growth and hypertensive action) have been attributed to NOS stimulation in endothelial cells through an increase
of cytosolic calcium, notwithstanding the scavenging activity of phenolics on NO and superoxide. In this paper, we determine
the concentration of cytosolic calcium in human lymphomonocytes incubated with high concentrations of NO-donors (CysNO) and
we evaluate the effects of olive oil phenolics on this parameter. CysNO induces a marked decrease of cytosolic calcium; both
olive oil phenolics oppose this action of CysNO. The effects of phenolics and CysNO are independent and additive. (Mol Cell
Biochem xxx: 181–184, 2005) |
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| Keywords: | cytosolic calcium olive oil phenolics nitric oxide nitrosocysteine |
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