In vitro killing of tumor cells by soluble products of activated guinea pig peritoneal macrophages |
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| Authors: | S D Sharma W F Piessens G Middlebrook |
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| Affiliation: | 1. Departments of Medicine, Harvard Medical School and Robert B. Brigham Hospital, Boston, Massachusetts 02115 USA;2. The Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 22101 USA |
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| Abstract: | ![]()
A partially purified fraction from supernatants of macrophage cultures from BCG-infected guinea pigs, which is rich in anti-Listeria activity, was cytotoxic to malignant and not normal cells. The susceptibility of target cells to this material varied considerably. Concentrations of egg white lysozyme, equal to those of the macrophage product, had considerably less effect on line 1 hepatoma cells. |
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| Keywords: | To whom all correspondence should be sent: 860 Bryant Street Palo Alto Calif. 94301. |
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