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Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells |
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| Authors: | Seyeon Park Sohyun Chun |
| Institution: | Department of Applied Chemistry, Dongduk Women''s University, Seoul 136-714, Republic of Korea |
| Abstract: | |
| Keywords: | APC Axin-adenomatous polyposis coli BCA bicinchoninic acid CBP CREB binding protein CRC colorectal cancer DMSO dimethyl sulfoxide Dsh disheveled EMSA electrophoretic mobility shift assay GAPDH glyceraldehyde 3-phosphate dehydrogenase GSK glycogen sythase kinase IC50 half maximal inhibitory concentration Lef lymphoid enhancer factor NF-κB nuclear factor-κB PCR polymerase chain reaction SDS sodium dodecyl sulfate TBE Tris base boric acid EDTA TBS Tris buffered saline TBST Tris buffered saline and Tween-20 Tcf T-cell factor |
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