具有保肝作用的天然药物开发进展

肝脏是机体代谢的最主要场所,也是机体最容易遭受到损伤的脏器之一,各种因素引起的肝损伤已成为威胁人类健康的重要疾病之一。肝损伤机制主要与线粒体损伤、自由基脂质过氧化、炎症细胞因子分泌和细胞膜损伤有关。目前已报道很多天然药物具有显著保肝作用,且具有疗效稳定、副作用低、多途径作用、作用温和持久等优势,已广泛用于肝脏疾病的防治。本文对肝损伤的生理机制以及具有保肝作用的天然药物开发进展进行了综述,提出了目前存在的一些问题并进行了展望。

Progress on the development of natural medicines with hepatoprotective effects

Liver is not only the most important metabolism organ,but also one of the most vulnerable organs.Liver injury caused by different kinds of factors has become an important disease that threatens human health.The mechanism of liver injury is mainly involved with mitochondrial injury,lipid peroxidation of free radical,secretion of inflammatory cytokines and cell membrane injury.It is recently reported that many natural medicines have significant hepatoprotective effects,with such advantages as stable efficacies,low-side effects,multiple pathways and mild and lasting effects.Thus,they have been widely used in the treatment of liver diseases.In this paper,the physiological mechanism of liver injury and development of natural medicines with hepatoprotective effects are reviewed.Furthermore,the existing problems and prospects are also proposed.