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Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones
Authors:Hutson Thomas H  Foster Edmund  Dawes John M  Hindges Robert  Yáñez-Muñoz Rafael J  Moon Lawrence D F
Institution:Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London, UK. thomas.hutson@kcl. ac.uk
Abstract:
Keywords:CNS  interferon response  integration‐deficient  lentiviral vector  neurones  RNA interference  shRNA
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