Differential responses of N-nitrosoamines and aromatic amines in the plant cell/microbe coincubation assay |
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Authors: | T Gichner E D Wagner M J Plewa |
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Institution: | 1. Institute of Experimental Botany, Academy of Science of the Czech Republic, Na Karlovce la, 160 00, Prague 6, Czech Republic 2. Institute for Environmental Studies, University of Illinois at Urbana-Champaign, 6180I, Urbana, IL, USA
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Abstract: | The plant cell/microbe coincubation assay is based on employing living tobacco cells in suspension culture as the activating system for promutagens and the Ames/Salmonella cells as the genetic indicator system. In contrast to aromatic amines(e.g. 2-aminofluorene andm-phenylenediamine) that were previously reported to be activated to products mutagenic in theS. typhimurium strains TA98 or YG1024 by tobacco cells, promutagenic N-nitrosoamines (N-nitrosodimethylamine, N-nitroso-morpholine, N-nitrosopiperidine, N-nitrosomethyl-2-hydroxypropylamine) were not activated to product(s) mutagenic inS. typhimurium TA 100. |
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