Survivin、Dnmt 和CD44 在胃溃疡及胃癌中表达的差异

胃溃疡(Gastric Ulcer GU)和胃癌(Gastrio Cancer Gc)均是我国乃至全世界人群中的常见病、多发病。近年来,虽然胃溃疡的发病率开始呈下降趋势,但仍属消化系统疾病中最常见的疾病之一,目前已被认为是癌前病变之一。据统计,5%左右的胃溃疡可发生癌变,甚至有统计最高达29.4%的胃癌来自胃溃疡1]。在世界范围内恶性肿瘤中,胃癌位居第4,病死率位居第2,在我国则居第1位。胃癌发生的分子机制研究表明多基因变异是细胞发生癌变的内因2]。各种癌基因、抑癌基因和错配修复基因、细胞信号传导通路的异常、细胞周期调控改变及相关产物均对胃癌的发生发展产生影响。如Survivin、DNA甲基化和CD44等均是近年来在胃癌组织中发现的并成为研究热点的基因。通过对Survivin、Dnmt和CD44三种基因在胃溃疡及胃癌中表达的差异的了解,有助于加深对胃癌发生、发展及转移机制的认识,更好的为临床应用中胃溃疡及胃癌的治疗提供理论依据和找到更好的治疗方法。

Survivin, Dnmt and CD44 Expression Difference in the Gastric Ulcer and Gastric Cancer

Gastric Ulcer, Gastric Ulcer GU) and Gastric cancer (GastrioCancer Gc) is a common disease, frequently-occurring disease in our country and the world population. In recent years, the incidence of gastric ulcer has shown a downward trend, but it remains one of the most common diseases of digestive system disease, and has been regarded as one of precancerous lesions. According to statistics, about 5%of the gastric ulcer can arise, even have statistics of up to 29.4%of gastric cancer fromgastric ulcer 1]. In malignant tumors throughout the world, gastric cancer ranks No. 4 with the 2nd fatality rate, while, in our country is No. 1. Studies on the molecular mechanisms of gastric cancer have shown that genetic variation is the internal cause of cell canceration 2]. A variety of actors, such as oncogenes, tumor suppressor genes and mismatch repair genes, cell signaling pathways of anomalies, changes in cell cycle regulation and related products, have certain influence on the occurrence and development of gastric cancer, among which Survivin, DNA methylation and CD44 have always been found in gastric cancer tissues in recent years and have become the research hotspot of genes. Understanding the differences in the expression of Survivin, Dnmt and CD44 in the gastric ulcer and gastric cancer helps to deepen the understanding of mechanisms of gastric cancer development and metastasis, which provides further theoretical basis for the treatment of gastric ulcer and gastric cancer in clinical application theoretical basis and finding better treatments.