Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands |
| |
Authors: | de Goede Janette Verschuren W M Monique Boer Jolanda M A Kromhout Daan Geleijnse Johanna M |
| |
Institution: | Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. |
| |
Abstract: | BackgroundWhether intake of alpha-linolenic acid (ALA), the plant-derived n-3
polyunsaturated fatty acid (PUFA), could prevent cardiovascular diseases is
not yet clear. We examined the associations of ALA intake with 10-year
incidence of coronary heart disease (CHD) and stroke in the Netherlands.MethodsData were collected from a general population of 20,069 generally healthy men
and women, aged 20 to 65 years. Habitual diet was assessed at baseline
(1993–1997) with a validated 178-item food frequency questionnaire.
Incidences of CHD and stroke were assessed through linkage with mortality
and morbidity registers. Hazard ratios (HR) were calculated with
multivariable Cox proportional hazards models, adjusted for age, gender,
lifestyle, and dietary factors.ResultsDuring 8–13 years of follow-up, we observed 280 incident CHD events
(19% fatal) and 221 strokes (4% fatal). Intakes of
energy-adjusted ALA in quintiles ranged from less than 1.0 g/d in the bottom
quintile (Q1) to more than 1.9 g/d in the top quintile (Q5). ALA intake was
not associated with incident CHD, with HRs varying between 0.89 and 1.01
(all p>0.05) in Q2–Q5 compared with the bottom quintile of ALA
intake. For incident stroke, however, participants in Q2–Q5 had a
35–50% lower risk compared with the reference group. HRs were
0.65 (0.43–0.97), 0.49 (0.31–0.76), 0.53 (0.34–0.83), and
0.65 (0.41–1.04) for Q2–Q5 respectively.ConclusionIn this general Dutch population, ALA intake was not associated with incident
CHD. The data suggested that a low intake of ALA may be a risk factor for
incident stroke. These results warrant confirmation in other
population-based studies and in trials. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|