|
|||||
|
|
HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs |
|
| Authors: | Zhang Jian-Ping Yang Zhi-Xue Zhang Feng Fu Ya-Wen Dai Xin-Yue Wen Wei Zhang Beldon Choi Hannah Chen Wanqiu Brown Meredith Baylink David Zhang Lei Qiu Hongyu Wang Charles Cheng Tao Zhang Xiao-Bing |
| Affiliation: | 1.State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China ;2.School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA ;3.Center for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA ;4.CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, 300020, China ;5.Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin, 300020, China ;6.Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, Tianjin, 300020, China ;7.Tianjin Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, 300020, China ;8.Center of Molecular and Translational Medicine, Institution of Biomedical Science, Georgia State University, Atlanta, GA, 30303, USA ; |
| Abstract: | Science China Life Sciences - Genome-edited human induced pluripotent stem cells (iPSCs) hold great promise for therapeutic applications. However, low editing efficiency has hampered the... |
| Keywords: | |
| 本文献已被 CNKI SpringerLink 等数据库收录！ | |