Association analyses of a SNP in the promoter of IGF1 with fat deposition and carcass merit traits in hybrid, Angus and Charolais beef cattle |
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| Authors: | K. K. Islam M. Vinsky R. E. Crews E. Okine S. S. Moore D. H. Crews Jr C. Li |
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| Affiliation: | Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada;. Agriculture and Agri-Food Canada, Lacombe Research Centre, 6000 C&E Trail, Lacombe, Alberta T4L 1W1, Canada;. Agriculture and Agri-Food Canada, Lethbridge Research Centre, 5403-1st Avenue South, Lethbridge, Alberta T1J 4B1, Canada;. Department of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA |
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| Abstract: | A SNP in the promoter region of insulin like growth factor-1 ( IGF1 ) (c.−512C>T) was analysed for associations with 10 fat deposition and carcass merit traits in hybrid ( n = 455), Angus ( n = 204) and Charolais ( n = 186) beef cattle populations. Significant associations of the SNP were found for ultrasound backfat thickness ( P = 0.030), carcass average backfat ( P = 0.015) and carcass lean meat yield (LMY) ( P = 0.023) in the Angus beef population, with the 'CC' genotype showing higher fat depth and lower LMY than the 'TT' genotype. Analyses of transcription factor binding sites based on transcription element search system prediction revealed that the 'C' allele introduces a binding site for nuclear factor I, which has an adipose tissue-specific regulatory role and thus may contribute to the SNP effect on fat deposition in the population of pure Angus cattle, a breed with greater fat depth than the hybrid and Charolais breeds. |
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| Keywords: | candidate gene cattle insulin like growth factor-1 single nucleotide polymorphism |
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