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Reaction of No With O2-. Implications for the Action of Endothelium-Derived Relaxing Factor (EDRF) |
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| Authors: | Manfred Saran Christa Michel Wolf Bors G Czapski |
| Abstract: | Under physiological pH conditions (pH 7.2-7.4) the rate constant of the reaction NO + O2 yielding peroxonitrite (ONOO) was determined as k = (3.7 ± 1.1) × 107 M 1 s 1. The decay of peroxonitrite at this pH follows first order kinetics with a rate constant of 1.4 s 1. At alkaline pH peroxonitrite is practically stable.
Possible consequences of these reactions for the biological lifetime of EDRF will be discussed. |
| Keywords: | Superoxide anion nitric oxide peroxonitrite endothelial derived relaxation factor biological messenging |
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