Facile and stereoselective synthesis of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst. |
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| Authors: | M Shimazu K Shinozuka H Sawai |
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| Affiliation: | Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu City, Japan. |
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| Abstract: | The synthesis and characterization of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst are described. The polymerization of imidazole-activated thioadenylate or thioinosylate yielded oligomers containing mainly 2'-5'-internucleotidyl blond and Rp configuration at phosphorous atom. |
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