Changes in lipid composition of tritosomes during lysis |
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| Authors: | W B Weglicki R C Ruth K Owens |
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| Institution: | 1. Cardiovascular Research Division Department of Medicine Peter Bent Brigham Hospital Boston, Massachusetts 02115 U.S.A.;2. Harvard Medical School Boston, Massachusetts 02115 U.S.A. |
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| Abstract: | Membrane phospholipids and free fatty acids were analyzed after lysis of lysosomes which had engulfed Triton WR 1339 (tritosomes). Significant elevations of lysophosphatidyl choline and lysophosphatidyl ethanolamine were seen. Phosphatidyl choline, phosphatidyl ethanolamine and sphingomyelin decreased significantly. Triglyceride also fell. The released free fatty acids paralleled closely the liberation of β-glucuronidase from the tritosomes. Thus, lipases hydrolyzed endogenous phospholipids and neutral lipids of tritosomes during incubation at 37°C at pH 5.0 to produce significant elevations of lysophospholipids and free fatty acids. The known surface-active properties of these latter compounds raise the possibility of their participation in the process of lysis of the tritosomes. |
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| Keywords: | Address correspondence to William B Weglicki M D Cardiovascular Research Department of Medicine Peter Bent Brigham Hospital 721 Huntington Avenue Boston Massachusetts 02115 |
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