| CD8+T细胞在多发性硬化中的致病性作用 |
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| 引用本文： | 梅云华,徐凌云.CD8+T细胞在多发性硬化中的致病性作用[J].生命科学,2006,18(3):244-246. |
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| 作者姓名： | 梅云华 徐凌云 |
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| 作者单位： | 上海交通大学医学院,上海市免疫学研究所,中国科学院上海生命科学研究院/上海交通大学医学院,健康科学中心,上海,200025 |
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| 基金项目： | 中科院知识创新工程(J0171-1903)
上海市重点学科建设项目(T0206)
上海市青年科技“启明星”计划(04QMX1423) |
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| 摘 要： | 多发性硬化是T细胞介导的自身免疫性疾病。先前对它的研究大多集中在CD4 T细胞的致病和调节性作用上,但是,近几年来越来越多的证据表明CD8 T细胞也参与多发性硬化的病理损伤过程。 CD8 T细胞存在于MS病灶部位,髓鞘抗原特异性CD8 T细胞也从MS患者的血液和脑脊液中分离得到,CD8 T细胞通过直接杀伤或释放细胞因子和趋化因子等间接参与MS的病理过程。本文就近几年关于CD8 T细胞在多发性硬化中的致病性作用的研究进展予以介绍。
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| 关 键 词： | CD8 T细胞 CD4 T细胞 多发性硬化 实验性自身反应性脑脊髓炎 |
| 文章编号： | 1004-0374（2006）03-0244-03 |
| 收稿时间： | 2005-12-20 |
| 修稿时间： | 2006-02-22 |
The pathogenic roles of CD8+ T cells in multiple sclerosis |
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| MEI Yun-Hua,XU Ling-Yun.The pathogenic roles of CD8+ T cells in multiple sclerosis[J].Chinese Bulletin of Life Sciences,2006,18(3):244-246. |
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| Authors: | MEI Yun-Hua XU Ling-Yun |
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| Institution: | Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiaotong University School of Medicine |
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| Abstract: | Multiple sclerosis (MS) is a T cell mediated autoimmune disease. Previous researches focus on the roles of CD4 T cells, including the pathogenic and immune-regulatory roles. However, more and more evidences show that CD8 T cells act as an important factor in the development of MS. CD8 T cells were founded in the lesions of MS, and myelin antigen specific CD8 T clones were isolated from MS patients. The autoreactive CD8 T cells can damage target cells directly or amplify local inflammation through secreting cytokines and chemokines. Illustrating the roles of CD8 T cells in MS will help us better understand the mechanisms of MS and find new prevention and therapeutic methods. |
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| Keywords: | CD8 T cells CD4 T cells multiple sclerosis experimental autoimmune encephalomyelitis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
