Phenylalanine metabolites as indicators of dietary compliance in children with phenylketonuria |
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Authors: | K Michals M Lopus R Matalon |
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Institution: | Department of Nutrition, University of Illinois, Chicago 60612. |
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Abstract: | The data from this study showed that the excretion of three major metabolites of phenylalanine in patients with PKU approach normal values at blood phenylalanine levels less than 5.0 mg/dl. The MANOVA showed statistically significant differences in phenyllactate excretion when blood phenylalanine was greater than 10.0 mg/dl. The PL and total metabolite excretion were significantly correlated to blood phenylalanine in multiple samples taken from two individual subjects. Using data obtained from single patient observations may serve as a means for individualizing the PKU diet to insure low levels of phenylalanine metabolites and thus insure optimal development for patients with PKU. |
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