Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro |
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Authors: | Jiajun Chen Lei Zhang Miao Hao |
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Institution: | 1. Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun 130033, China;2. Science Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, China |
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Abstract: | Artemisinin is the first-line drugs for the treatment of malaria. In recent years, a large number of reports showed that artemisinin exhibit anti-tumor activity. In this study, we used C6 glioma cells and rat C6 brain-glioma model to study anti-tumor activity of artemisinin in vivo and in vitro. We found that artemisinin inhibited the proliferation in C6 cells and induced cell cycle arrest and a caspase-3-dependent cell apoptosis. It also inhibited the growth of C6 brain-glioma in vivo and enhanced living state of rat brain-glioma model. These results suggested that artemisinin had significant anti-tumor activities on C6 cells both in vitro and in vivo. Artemisinin might be exploited as a promising clinical anti-cancer drug in future. |
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Keywords: | Artemisinin Glioma Anti-tumor C6 Apoptosis |
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