Synovial tissues concentrate secreted APRIL |
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| Authors: | Cem Gabay Veit Krenn Carine Bosshard Alexander Christian Seemayer Carlo Chizzolini Bertrand Huard |
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| Affiliation: | (1) Division of Rheumatology, University Hospitals, 4 rue Gabrielle Perret-Gentil, Geneva, CH, 1211, Switzerland;(2) Department of Pathology-Immunology, Faculty of Medicine, 1 rue Michel Servet, Geneva, CH, 1211, Switzerland;(3) Cytology and Molecular Diagnostic, Histology Center, Max Planck Street, Trier, D-54296, Germany;(4) Division of Hematology, 4 rue Gabrielle Perret-Gentil, Geneva, CH, 1211, Switzerland;(5) Department of Pathology, Faculty of Medicine, 1 rue Michel Servet, Geneva, CH, 1211, Switzerland;(6) Current address: Rheumatology, University Hospitals, 46 rue du Bugnon, Lausanne, CH, 1011, Switzerland;(7) Division of Immunology and Allergy, 4 rue Gabrielle Perret-Gentil, Geneva, CH, 1211, Switzerland |
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| Abstract: | Introduction A proliferation-inducing ligand (APRIL) from the TNF family, owing to its role in the generation and survival of plasma cells (PCs), is currently targeted for rheumatoid arthritis (RA) treatment. However, little is known about APRIL expression in RA lesions, hampering our understanding of the way APRIL may modulate this autoimmune disease. |
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