| Institution: | (1) Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, 06520 New Haven, CT, USA;(2) Department of Zoology, University of Toronto, Toronto, M5S 3G5, ON, Canada;(3) Centers for Disease Control and Prevention, Mailstop F22, Chamblee, 30334, GA, USA |
| Abstract: | Background
Anopheles gambiae females are the world's most successful vectors of human malaria. However, a fraction of these mosquitoes is refractory to
Plasmodium development. L3-5, a laboratory selected refractory strain, encapsulates transforming ookinetes/early oocysts of a wide variety
of Plasmodium species. Previous studies on these mosquitoes showed that one major (Pen1) and two minor (Pen2, Pen3) autosomal dominant quantitative trait loci (QTLs) control the melanotic encapsulation response against P. cynomolgi B, a simian malaria originating in Malaysia. |
