| 中国人群5-羟色胺2A受体基因中T102C多态性与精神分裂症的联系Analysis of Association Between T102C Polymorphism in theSerotonin 2A Receptor Gene and Schizophrenia in Chinese Population |
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| 作者姓名： | 李胜 顾牛范 冯国鄞 刘万清 沈韬 贺林 LI Sheng GU Niu-fan FENG Guo-yin LIU Wang-qing SHEN Tao HE Lin |
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| 作者单位： | 1.中国科学院上海生命科学研究中心,上海 2000312.上海市井绳卫生中心，上海 2000313.中国科学院上海脑研究所1.Shanghai Research Center of Life Science,Chinese Academy of Sciences,Shanghai 2000312.Shanghai Mental Health Center,Shanghai 2000303.Shanghai Brain Research Instiute,Chinese Academy of Sciences,Shanghai 200031 |
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| 摘 要： | 在研究5-羟色胺2A受体基因多态性与精神分裂症的关联分析中,调查了20 2例精神分裂症患者及202例正常对照。各相匹配组间比较未发现基因型和等位基因频率的显著性差异。结果提示,在中国人群中5-羟色胺2A受体的静态T102C突变与精神分裂症之间不存在关联。Abstract:Association study between in the T102C polymorphism serotonin 2A receptor gene and schizoprenia was performed in 202 schizophrenics and 202 normal controls.No significant differences of genotype and allele frequencies between the matched groups were found.Our results,which are different from some other studies,excluded the association between a silent T102C change and schizophrenia in the Chinese population.
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| 关 键 词： | 5-羟色胺2A受体基因多态性 精神分裂症 Key words serotonin 2A receptor gene polymorphism Schizophrenia |
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