Role of Murine Intestinal Interleukin-1 Receptor 1-Expressing Lymphoid Tissue Inducer-Like Cells in Salmonella Infection |
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| Authors: | Vincent L. Chen Neeraj K. Surana Jinyou Duan Dennis L. Kasper |
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| Affiliation: | 1. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.; 2. Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America.; 3. College of Science, Northwest A&F University, Yangling, China.; Massachusetts General Hospital, United States of America, |
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| Abstract: | ![]()
Interleukin (IL)-1 signaling plays a critical role in intestinal immunology. Here, we report that the major population of intestinal lamina propria lymphocytes expressing IL-1 receptor 1 (IL-1R1) is the lymphoid tissue inducer (LTi)-like cell, a type of innate lymphoid cell. These cells are significant producers of IL-22, and this IL-22 production depends on IL-1R1 signaling. LTi-like cells are required for defense against Salmonella enterica serovar Typhimurium. Moreover, colonic LTi-like cell numbers depend on the presence of the intestinal microbiota. LTi-like cells require IL-1R1 for production of protective cytokines and confer protection in infectious colitis, and their cell numbers in the colon depend upon having a microbiome. |
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