Preimplantation genetic diagnosis in Saudi Arabia |
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Authors: | Zeinab Abotalib |
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Institution: | Department of Obstetrics and Gynecology, King Khalid University Hospital, College of Medicine, King Saud University P.O. Box 60826, Riyadh 11555, Kingdom of Saudi Arabia |
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Abstract: | Preimplantation genetic diagnosis (PGD) testing is the practice of obtaining a cellular biopsy sample from a developing human
oocyte or embryo, acquired via a cycle of in vitro fertilization (IVF); evaluating the genetic composition of this sample; and using
this information to determine which embryos will be optimal for subsequent uterine transfer. PGD has become an increasingly
useful adjunct to IVF procedures. The ability to provide couples who are known carriers of genetic abnormalities the opportunity
to deliver healthy babies has opened a new frontier in reproductive medicine. The purpose of the PGD is enables us to choose
which embryos will be implanted into the mother. In the present study 137 families who had undergone IVF at Habib Medical
Centre, were enrolled for the PGD analysis. The couple visited the clinic for the sex selection, recurrent fetal loss and with the
recurrent IVF failure. 802 embryos were tested by the biopsy method and 512 are found to be normal and 290 were abnormal
embryos. In this study only 24% of the embryos were transferred and the remaining was not transferred because of the
abnormalities or undesired sex of the embryos. The structural and numerical abnormalities were found to be 16.8%. |
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Keywords: | Preimplantation genetic diagnosis (PGD) invitro fertilization (IVF) Biopsy Saudi Arabia |
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