Modeling cell-in-cell structure into its biological significance |
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Authors: | M-f He S Wang Y Wang X-n Wang |
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Institution: | 1.The Institute of Life Sciences, Chinese PLA General Hospital and SCUT, the State Key Laboratory of Kidney Disease,, Beijing 100853, China;2.Shanghai Institute of Immunology, Institute of Medical Sciences, Shanghai Jiaotong University, School of Medicine, Shanghai 200025, China |
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Abstract: | Although cell-in-cell structure was noted 100 years ago, the molecular mechanisms of ‘entering'' and the destination of cell-in-cell remain largely unclear. It takes place among the same type of cells (homotypic cell-in-cell) or different types of cells (heterotypic cell-in-cell). Cell-in-cell formation affects both effector cells and their host cells in multiple aspects, while cell-in-cell death is under more intensive investigation. Given that cell-in-cell has an important role in maintaining homeostasis, aberrant cell-in-cell process contributes to the etiopathology in humans. Indeed, cell-in-cell is observed in many pathological processes of human diseases. In this review, we intend to discuss the biological models of cell-in-cell structures under physiological and pathological status. |
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Keywords: | cell-in-cell cannibalism entosis emperitosis biological significance |
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