Effect of G(-174)C polymorphism in interleukin-6 gene on cardiovascular disease in type 2 diabetes patients |
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| Affiliation: | 1. Department of Endocrinology, Tan Tock Seng Hospital, Singapore;2. Yong Loo Lin School of Medicine, Singapore;3. Duke-NUS Graduate Medical School, Singapore;4. Brenner Centre for Molecular Medicine, National University of Singapore, Singapore;1. Fight AIDS and Infectious Diseases Foundation, Badalona, Spain;2. Hospital Universitari Germans Trias i Pujol, Barcelona Institute for Global Health, Rosselló, 132, Badalona 08036, Spain;3. ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain;4. Gerència Territorial Metropolitana Nord, Institut Català de la Salut, Barcelona, Spain;5. Universitat de Vic-Universitat Central de Catalunya (UVIC-UCC), Vic, Spain;6. Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique;7. ICREA, Pg. Lluís Companys 23, Barcelona 08010, Spain;8. Pediatrics Department, Hospital Sant Joan de Déu (University of Barcelona), Barcelona, Spain;9. Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;9. Lihir Medical Centre, International SOS Clinic, Lihir Island, Papua New Guinea |
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| Abstract: | ![]()
Interleukin-6 (IL-6) is an important pro-inflammatory cytokine of relevance to cardiovascular diseases. The aim of this case-control study was to evaluate the association between the G(-174)C functional polymorphism in the IL-6 gene and risk of cardiovascular disease (CVD) in type 2 diabetes patients. We examined 1090 patients with T2DM and 612 controls. All subjects were genotyped for the G(-174)C polymorphism by polymerase chain reaction (PCR) and restriction analysis. There were no significant differences in the distribution of genotypes and alleles between T2DM patients and healthy controls. Significantly higher C allele frequency was observed in CVD+ patients compared to CVD- subgroup (53% vs. 32%, p < 0.0001). The odds ratio for C allele was 2.4 (95% CI 1.99–2.9, p < 0.0001) and for CC genotype 4.55 (95% CI 3.12–6.63, p < 0.000). When the distribution of G(-174)C polymorphism was compared in subgroups with different clinical phenotypes of CVD, a significant association of CC genotype with myocardial infarction was observed. Forty eight percent of patients with MI had the CC genotype compared to 22% of patients without MI (p < 0.0001). In conclusion, type 2 diabetes patients carrying the C allele of the IL-6 G(-174)C polymorphism have a significantly increased risk of CVD. |
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| Keywords: | Interleukin-6 Cardiovascular disease Type 2 diabetes G(-174)C polymorphism Risk allele |
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