A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease |
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Authors: | Zhong Chen Qi Qian Genshan Ma Jiahong Wang Xiaoli Zhang Yi Feng Chengxing Shen Yuyu Yao |
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Institution: | (1) Department of Cardiology, The Affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao, Hunan Road, Nanjing, 210009, People’s Republic of China |
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Abstract: | Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated
with myocardial infarction. We investigated whether these two genetic markers are determinants of early-onset coronary artery
disease. Methods and results A total of 444 consecutive patients were studied including 212 cases with coronary stenosis ≥50% or previous myocardial infarction and 232 controls without documented coronary artery disease. Ligase detection reaction
was performed to detect two SNPs. After adjustment of clinical parameters, significant associations were identified for the
rs2383207 and rs10757278 SNPs, with A/G and G/G genetypes at rs10757278 and G/G genetype carriers at rs2383207 having a higher
risk of early-onset coronary artery disease than carriers of A/A genotype (odds ratio OR] 2.207, 95% CI: 1.069–4.394, P = 0.028; OR 3.051, 95% CI: 1.086–8.567, P = 0.004; OR 2.964, 95% CI: 1.063–8.265, P = 0.038, respectively). There were no associations between rs10757278 and rs2383207 genotypes and the severity of coronary
artery disease (both P > 0.05). Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease. These markers may help the
identification of patients at increased risk for early-onset coronary artery disease.
Zhong Chen and Qi Qian contributed equally to this paper. |
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Keywords: | Coronary artery disease Early-onset Single nucleotide polymorphisms Genetic Gene |
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