Human disease: calcium signaling in polycystic kidney disease |
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| Authors: | Somlo S Ehrlich B |
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| Affiliation: | Department of Internal Medicine, Yale University School of Medicine, Connecticut, New Haven, USA. stefan.somlo@yale.edu |
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| Abstract: | ![]()
Polycystic kidney disease results from loss of function of either of two novel proteins, polycystin-1 or polycystin-2. Recent studies show that intracellular calcium signaling is important in kidney development, and define defects in this signaling pathway as the basis of cyst formation in polycystic kidney disease. |
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