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Industrial production of monoclonal antibodies and therapeutic proteins by dialysis fermentation |
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| Authors: | Michael J. Comer Michael J. Kearns Jürgen Wahl Michael Munster Thomas Lorenz Berthold Szperalski Stefan Koch Ulrich Behrendt Herwig Brunner |
| Affiliation: | (1) Research Centre Penzberg, Boehringer Mannheim GmbH, Nonnenwald, 8122 Penzberg, Germany |
| Abstract: | A novel and powerful fermentation method is reported for the large-scale growth of mammalian cells and their secreted products. The system described illustrates many of the advantages of conventional batch fermentation processes but in addition has been shown to yield cell densities in excess of 1×107 cells/ml with concomitant increase in product concentration.Abbreviations MAb Monoclonal Antibody - STR Stirred Tank Reactor - FBS Foetal Bovine Serum |
| Keywords: | large-scale cultivation monoclonal antibodies therapeutic proteins |
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