Selective enhancement of the induction of alpha-lactalbumin activity in rat mammary explants by epidermal growth factor |
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Authors: | L Sankaran Y J Topper |
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Institution: | Laboratory of Biochemistry and Metabolism National Institutes of Arthritis, Diabetes, and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland 20205 USA |
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Abstract: | Epidermal growth factor (EGF) enhances the induction of alpha-lactalbumin in mammary explants from pregnant and virgin rats in the presence of insulin (I), hydrocortisone (F) and prolactin (P). EGF also enhances the prolactin-independent induction of alpha-lactalbumin in tissue from pregnant rats and evokes prolactin-independent induction of alpha-lactalbumin in mammary tissue from virgin rats in the presence of I and F. Casein synthesis and galactosyltransferase activity are unaffected by EGF in the IFP-system, and are not induced in the IF-EGF-system. Multiplication stimulating activity, nerve growth factor, fibroblast growth factor and platelet-derived growth factor do not mimic the selective effects of EGF on rat alpha-lactalbumin. These influences of EGF on the differentiation of isolated rat mammary tissue are compared with those on mouse and rabbit tissue studied previously. |
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