Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy |
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| Authors: | Zhang Qi Chen Guihua Liu Xinyuan Qian Qijun |
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| Institution: | Qi Zhang~1 Guihua Chen~1 Xinyuan Liu~2 Qijun Qian~3 ~1Transplantation Research Institute of Sun Yat-sen University,The Third Affiliated Hospital of Sun Yat-Sen University,600 Tianhe Rd,Guangzhou 510630,China,~2Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China, ~3Laboratory of Viral and Gene Therapy,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,225 Changhai Rd,Shanghai 200438,China |
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| Abstract: | Antibodies as therapeutic agents are mostly used in oncology, as illustrated by their applications in lymphoma, breast cancer or colorectal cancer. This review provides a brief historical sketch of the development of monoclonal antibodies for cancer treatment and summarizes the most significant clinical data for the best-established reagents to date. It also discusses strategies to improve the anti-tumor efficacy of antibody therapy, including antibody gene therapy and exploitation of bone marrow derived primary mesenchymal stem cells as the antibody gene transporter. |
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| Keywords: | monoclonal antibody cancer gene therapy |
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