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Cyclic urea derivatives as potent NK1 selective antagonists |
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| Authors: | Shue Ho-Jane Chen Xiao Shih Neng-Yang Blythin David J Paliwal Sunil Lin Ling Gu Danlin Schwerdt John H Shah Sapna Reichard Gregory A Piwinski John J Duffy Ruth A Lachowicz Jean E Coffin Vicki L Liu Fei Nomeir Amin A Morgan Cynthia A Varty Geoffrey B |
| Affiliation: | Chemical Research Department, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. |
| Abstract: | A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein. |
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