The conversion of leukotriene C4 to isomers of leukotriene B4 by human eosinophil peroxidase |
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| Authors: | E J Goetzl |
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| Affiliation: | 1. Howard Hughes Medical Institute Laboratory, the University of California, San Francisco, San Francisco, California 94143 USA;2. the Division of Allergy and Immunology, the University of California, San Francisco, San Francisco, California 94143 USA |
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| Abstract: | The smooth muscle contractile and vasoactive mediator leukotriene C4 (5(S)-hydroxy-6(R)-sulfido-glutathionyl-eicosatetraenoic acid; LTC4) is converted by phorbol ester-stimulated human eosinophils to two isomers of leukotriene B4, 5(S),12(R)-6,8,10 trans-14 cis-eicosatetraenoic acid (5(S),12(R)-“all-trans”-LTB4) and 5(S),12(S)-“all-trans”-LTB4, which are leukocyte chemotactic factors lacking the humoral functions of LTC4. Optimal conversion of LTC4 to the “all-trans” isomers of LTB4 by intact eosinophils and soluble eosinophil peroxidase requires both H2O2 and halide ions. Oxidative metabolism of leukotrienes may represent an important regulatory function of eosinophils in hypersensitivity reactions. |
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