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Data fusion in metabolomic cancer diagnostics |
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| Authors: | Rasmus Bro Hans Jørgen Nielsen Francesco Savorani Karin Kjeldahl Ib Jarle Christensen Nils Brünner Anders Juul Lawaetz |
| Affiliation: | 1. Department of Food Science, University of Copenhagen, Rolighedsvej 30, Frederiksberg, 1958, Copenhagen, Denmark 2. Department of Surgical Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark 3. The Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark and Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark 4. Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, 1870, Copenhagen, Denmark |
| Abstract: | We have recently shown that fluorescence spectroscopy of plasma samples has promising abilities regarding early detection of colorectal cancer. In the present paper, these results were further developed by combining fluorescence with the biomarkers, CEA and TIMP-1 and traditional metabolomic measurements in the form of 1H NMR spectroscopy. The results indicate that using an extensive profile established by combining such measurements together with the biomarkers is better than using single markers. |
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