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Polycations. 17. Synthesis and properties of polycationic derivatives of carbohydrates |
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| Authors: | Marie Thomas Diego Montenegro Alejandra Castao Laura Friedman Jay Leb Mia Lace Huang Leah Rothman Heidi Lee Craig Capodiferro Daniel Ambinder Eva Cere Jessica Galante JaimeLee Rizzo Karin Melkonian Robert Engel |
| Institution: | aDepartment of Chemistry and Biochemistry, Queens College CUNY, 65-30 Kissena Boulevard, Flushing, NY 11367, USA;bDoctoral Program in Chemistry, The Graduate Center CUNY, 365 5th Avenue, New York, NY 10016, USA;cDepartment of Chemistry and Physical Sciences, Pace University, 1 Pace Plaza, New York, NY 11560, USA;dDepartment of Biology, Long Island University/C.W. Post Campus, 720 Northern Boulevard, Greenville, NY 11548, USA |
| Abstract: | In our continuing investigation of polycationic salts for purposes of antimicrobial action, ion-channel blocking, and construction of ionic liquids, we have prepared several series of polycationic salts derived from carbohydrate precursors. These salts are currently being investigated for optimal efficacy as antibacterials and antifungals, as well as for other applications. The syntheses of such series of salts are described here along with preliminary antibacterial testing results and a discussion of their properties indicating their potential utility for several purposes. |
| Keywords: | Cationic carbohydrates Alditol derivatives Lipids Salts Antibacterial |
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