Synthesis of 2-chloro-4-nitrophenyl alpha-L-fucopyranoside: a substrate for alpha-L-fucosidase (AFU) |
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| Authors: | Gu Guofeng Du Yuguo Hu Hongyan Jin Cheng |
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| Institution: | Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Academia Sinica, 18 Shuangqing Road Haidian District, P.O. Box 2871, Beijing 100085, PR China. |
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| Abstract: | An effective method to prepare the substrate of alpha-L-fucosidase (AFU) is described. Ethyl 1-thiofucoside with a free 2-OH group was used as the glycosyl donor, and there was found no self-condensed side product. The use of the HF.pyridine reagent to remove the silyl protecting group in the last step afforded a target molecule of high purity. |
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| Keywords: | l-Fucosidase" target="_blank">α-l-Fucosidase Hepatocellular carcinoma Glycosylation |
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