干细胞改善糖尿病的分子机制及临床研究进展

糖尿病是各种因素导致的高血糖慢性代谢疾病,已发展成为流行疾病之一。化学抗糖药虽能控制血糖水平,延缓病程进展,但需长期服用;胰岛移植能从根本上治愈糖尿病,但胰岛来源不足,且需终生应用免疫抑制剂,故并没有得到广泛应用;干细胞是一类能够自我复制的细胞,具有多向分化潜能和旁分泌特性,近年来的研究证明,干细胞在糖尿病治疗方面有着积极的效果,被认为是有效治疗糖尿病的理想细胞类型。因此,就干细胞治疗糖尿病的分子机制和临床研究现状进行简要阐述。

Molecular Mechanism and Clinical Research Progress of Mesenchymal Stem Cells in the Treatment of Diabetes Mellitus

Diabetes is a chronic metabolic disease of hyperglycemia caused by various factors, which has developed into one of the epidemic diseases. Chemical anti-diabetic drugs can control the blood glucose and delay the progress of the disease, which needs to be taken for a long time to be effectively controlled. The current gold standard therapy for pancreas transplantation, but it has not been widely used because of the shortage of pancreas and the need for long-term use of immunosuppressive drugs. Mesenchymal stem cells (MSCs) are a kind of self-proliferation cells with the potential of multi-directional differentiation and paracrine characteristics. Recent studies have proved that MSCs have positive effects in the treatment of diabetes, and are considered as the ideal cell type for treatment of diabetes. Therefore, this review The molecular mechanisms and clinical research of MSCs for diabetes mellitus were briefly described.