|
|||||
|
|
Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro |
|
| Authors: | Pedro Madalena Cerqueira Fátima Sousa Maria Emília Nascimento Maria São José Pinto Madalena |
| Institution: | a Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto, Faculdade de Farmácia, Rua Aníbal Cunha, 164, 4050-047, Porto, Portugal b Instituto Superior das Ciências da Saúde-Norte, Rua Central da Gandra, 1317, 4580, Gandra, Portugal |
| Abstract: | Twenty-seven oxygenated xanthones have been assessed for their capacity to inhibit in vitro the growth of three human cancer cell lines, MCF-7 (breast cancer), TK-10 (renal cancer) and UACC-62 (melanoma). The effect of these xanthones on the proliferation of human T-lymphocytes was also evaluated. Differences on their potency towards the effect on the growth of the human cancer cell lines as well as on the proliferation of human T-lymphocytes can be ascribed to the nature and positions of the substituents on the xanthonic nucleus. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |