DNA gyrase and its complexes with DNA: direct observation by electron microscopy |
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Authors: | T Kirchhausen J C Wang S C Harrison |
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Affiliation: | Department of Biochemistry and Molecular Biology Harvard University 7 Divinity Avenue Cambridge, Massachusetts 02138, USA |
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Abstract: | Electron microscopy of DNA gyrase holoenzyme, of gyrase A subunits, and of the complexes of both species with DNA enables us to deduce the relative locations of subunits in the holoenzyme and to indicate a plausible path for DNA complexed with gyrase. The structural results are discussed in terms of certain models for directional DNA strand transport. |
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