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Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease |
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| Authors: | Joung Wook Lee Hong Namkoong Hyun Kee Kim Sanghee Kim Dong Whi Hwang Hae Ri Na Seon-Ah Ha Jae-Ryong Kim Jin Woo Kim |
| Institution: | (1) Department of Neurology, Bobath Memorial Hospital Bundang-Gu, Seongnam, Gyungki-do, 463-805, Korea;(2) Molecular Genetic Laboratory, College of Medicine, The Catholic University of Korea, 137-040 Seoul, Korea;(3) Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, 137-040, Korea;(4) Department of Biochemistry and Molecular Biology, Aging-assoiciated Vascular Disease Research Center, College of Medicine Yeungnam University, Daegu, Korea |
| Abstract: | BackgroundCerebrospinal fluid (CSF) may be valuable for exploring protein markers for the diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to slow progression, holds hope for aging populations with increased average lifespan. The aim of the present study was to investigate candidate CSF biological markers in patients with mild cognitive impairment (MCI) and AD and compare them with age-matched normal control subjects. |
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