Transduction of cell and matrix geometric cues by the actin cytoskeleton |
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| Affiliation: | 1. Department of Bioengineering, University of California, Berkeley, CA, 94720, USA;2. Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, 94720, USA;3. UC Berkeley-UCSF Graduate Program in Bioengineering, USA;1. Department of Systems and Synthetic Microbiology, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany;2. Flow Cytometry and Imaging Facility, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany;3. LOEWE Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany;1. Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8002, USA.;2. Department of Cell Biology, School of Medicine, Johns Hopkins University, 855 N Wolfe Street, Baltimore, MD, 21025, USA;1. Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA;2. Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA;1. Graduate Program in Cancer Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA;2. Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA;3. Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA;4. Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, 48109, USA;1. Biology Department, University of North Carolina, Chapel Hill, NC, 27599, USA;2. Marine Biological Laboratory, Woods Hole, MA, 02543, USA;1. State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China;2. College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China;3. Department of Chemical Engineering, University of New Brunswick, Fredericton, NB E3B 5A3, Canada |
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| Abstract: | Engineered culture substrates have proven invaluable for investigating the role of cell and extracellular matrix geometry in governing cell behavior. While the mechanisms relating geometry to phenotype are complex, it is clear that the actin cytoskeleton plays a key role in integrating geometric inputs and transducing these cues into intracellular signals that drive downstream biology. Here, we review recent progress in elucidating the role of the cell and matrix geometry in regulating actin cytoskeletal architecture and mechanics. We address new developments in traditional two-dimensional culture paradigms and discuss efforts to extend these advances to three-dimensional systems, ranging from nanotextured surfaces to microtopographical systems (e.g. channels) to fully three-dimensional matrices. |
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| Keywords: | Cell geometry Cytoskeleton Micropatterning Nanotopography 3D Confinement |
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