| 胃癌组织中Survivin、P53蛋白表达和微血管密度测定及意义 |
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| 引用本文： | 赫丽杰,刘云鹏,侯科佐.胃癌组织中Survivin、P53蛋白表达和微血管密度测定及意义[J].中国组织化学与细胞化学杂志,2009,18(3):299-303. |
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| 作者姓名： | 赫丽杰 刘云鹏 侯科佐 |
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| 作者单位： | 中国医科大学附属第一医院肿瘤内科,沈阳,110001 |
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| 摘 要： | 目的探讨Survivin,P53蛋白在胃癌组织中的表达及其与血管生成的关系。方法用免疫组化方法对65例胃癌组织Survivin,P53,CD34的表达进行检测。结果胃癌组织中Survivin蛋白阳性表达率为70.77%（46/65）,P53蛋白阳性表达率为64.62%（42/65）。Survivin表达与分化程度和淋巴结转移有关（P〈0.05）,而与临床分期无关（P〉0.05）;P53的阳性表达与分化程度、临床分期和淋巴结转移有关（P〈0.05）。Survivin表达与P53的表达密切相关（r=0.413,P〈0.01）。Survivin阳性表达组织中的MVD值为103.04±15.06,阴性组为81.89±12.15,二者有显著差异（P〈0.01）。P53阳性表达胃癌组织中的MVD值为105.83±15.06,阴性组为81±12.71,二者有显著差异（P〈0.01）。结论Survivin和P53突变对凋亡的抑制的协同作用及其促进血管生成的作用在胃癌的发生发展中起关键作用。
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| 关 键 词： | 生存素 P53 微血管密度 胃癌 |
EXPRESSION AND SIGNIFICANCE OF SURVIVIN,P53 AND MVD IN GASTRIC CANCER |
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| He Lijie,Liu Yunpeng,Hou Kezuo.EXPRESSION AND SIGNIFICANCE OF SURVIVIN,P53 AND MVD IN GASTRIC CANCER[J].Chinese Journal of Histochemistry and Cytochemistry,2009,18(3):299-303. |
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| Authors: | He Lijie Liu Yunpeng Hou Kezuo |
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| Institution: | He Lijie,Liu Yunpeng,Hou Kezuo(Department of Medical Oncology,The First Affiliated Hospital of China Medical University,Shenyang 110001,China) |
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| Abstract: | Objective To investigate the expression of survivin mRNA and P53 and their relationship with angiogenesis in gastric cancer.Methods The expression of survivin,P53 and CD34 in 65 cases of gastric cancer was examined by immunohistochemistry.Results The expression of survivin in gastric cancer was 70.77%(46/65),and the expression of P53 was 64.62%(42/65).The survivin expression was significantly associated with differentiation and lymph node metastasis(P<0.05) but not with clinical stages(P>0.05).The P53 expre... |
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| Keywords: | P53 |
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