From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility |
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| Authors: | Lanier L M Gertler F B |
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| Institution: | Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Imlanier@mit.edu |
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| Abstract: | The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated proteins may regulate cell adhesion and actin polymerization, thereby regulating growth cone motility during axonogenesis. |
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