| S抗原与抗体结合的扫描隧道显微镜研究 |
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| 引用本文： | 焦越坎,林克椿.S抗原与抗体结合的扫描隧道显微镜研究[J].中国生物化学与分子生物学报,1996,12(1):59-63. |
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| 作者姓名： | 焦越坎 林克椿 |
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| 作者单位： | 北京医科大学生物物理系，北京昌平石油大学机电工程系 |
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| 基金项目： | 国家教委博士点基金,国家自然科学基金 |
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| 摘 要： | 用扫描隧道显微镜观察了兔Ｓ抗原及其与鼠抗兔Ｓ抗原抗体相互作用所形成的复合物，结果表明，Ｓ抗原单体呈椭球状。其二维尺寸为７．５ｎｍ×５．３ｎｍ，且常以二聚体形式存在。抗原分别结合于抗体的二个Ｆａｂ段，既可以单体结合，也可以二聚体形式结合。
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| 关 键 词： | 扫描隧道显微镜 S抗原 抗原／抗体复合物 |
| 收稿时间： | 1996-02-20 |
A Scanning Tunneling Microscopic Study of S Antigen and Complex of S Antigen-Antibody |
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| Jiao Yue-Ken,Lin Ke-Chun.A Scanning Tunneling Microscopic Study of S Antigen and Complex of S Antigen-Antibody[J].Chinese Journal of Biochemistry and Molecular Biology,1996,12(1):59-63. |
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| Authors: | Jiao Yue-Ken Lin Ke-Chun |
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| Institution: | (Department of Biophysics, Beijing Medical University, Beijing 100083 |
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| Abstract: | Rabbit S antigen and its complex with antibody have been observed by scanning tunneling microscope(STM). The results showed that S antigen monomer appeared as ellipsoids, its two dimensional sizes are 7. 5 ×5. 3 nm,usually they existed as dimers or even polymers. Antigens combine with the two ends of Fab in the IgG molecule separately. They may be in the form of either monomers or dimers. This work illustrated the applicability of STM in the investigation of the interaction between antigen and antibody at the molecular level. |
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| Keywords: | Scanning tunneling microscope S antigen Antigen/antibody complex |
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