| 乳铁蛋白的理化性质及其重组表达系统的研究进展 |
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| 引用本文： | 庞晓楠,弘笑,魏璇,陈喜文,刘佳,陈德富.乳铁蛋白的理化性质及其重组表达系统的研究进展[J].遗传,2015,37(9):873-884. |
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| 作者姓名： | 庞晓楠 弘笑 魏璇 陈喜文 刘佳 陈德富 |
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| 作者单位： | 1. 药物化学生物学国家重点实验室(南开大学),天津300071; 2. 上海科技大学免疫化学研究所,上海201210; 3. 南开大学生命科学学院遗传学和细胞生物学系,天津300071; 4. 南开大学生命科学学院生物化学与分子生物学系,天津300071; |
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| 基金项目： | 药物化学生物学国家重点实验室开放基金(编号：201503017)、天津市应用基础与前沿技术研究计划重点项目(编号：112JCZDJC22900)和创新人才培养基金(编号：J1103503)资助 |
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| 摘 要： | 乳铁蛋白(Lactoferrin, Lf)是分子量大小约为80 kDa的铁离子结合糖蛋白,是转铁蛋白(Transferrin, Tf)家族的成员之一。其理化性质独特,具有抑菌、抗病毒、抗癌、免疫调节、调节铁离子的吸收等诸多生物学功能。获得高产且有生物活性的重组乳铁蛋白,并用于临床治疗,一直是研究热点。随着基因工程技术的发展,已获得多个可表达重组乳铁蛋白的表达系统。本文对乳铁蛋白的理化性质、生物学活性、临床研究以及目前的重组表达系统进行综述,以期为乳铁蛋白的临床应用提供参考。
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| 关 键 词： | 乳铁蛋白 抑菌 抗病毒 免疫调节 重组表达系统 |
| 收稿时间： | 2015-04-09 |
Research progress in physicochemical characteristics of lactoferrin and its recombinant expression systems |
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| Institution: | 1. State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin 300071, China; 2. Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, China; 3. Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin 300071, China; 4. Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China |
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| Abstract: | Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80 kDa that belongs to the transferrin family. Due to its unique physical and chemical properties, lactoferrin has a variety of biological functions including antibacterial, antiviral, anticancer, immunomodulatory activities and regulation of iron absorption. High-yield production of recombinant lactoferrin with biological activity and its application in clinical treatment have been a hot topic for long time. With the development of genetic engineering techniques, various expression systems have been developed to produce recombinant lactoferrin. In this review, we summarize physicochemical characteristics, biological activities, clinical studies and current recombinant expression systems of lactoferrin, in order to provide references for its clinical application. |
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| Keywords: | lactoferrin antibacterial antiviral immunomodulatory recombinant expression system |
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