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Nucleotide sequence-directed mapping of the nucleosomes of SV40 chromatin |
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| Authors: | G Mengeritsky E N Trifonov |
| Institution: | (1) Department of Polymer Research, The Weizmann Institute of Science, Rehovot, Israel |
| Abstract: | In our previous work we have shown by comparison of experimental and computational data that the positions of the histone octamers bound to the DNA molecule appear to be completely sequence-dependent. This provides a convenient and quick method for locating the nucleosomes along the DNA molecule, as soon as the nucleotide sequence is known. Using this computational approach, the complete nucleosomal map of the SV40 minichromosome has been constructed. The map consists of 25 nucleosomes, with their coordinates (centers) being specified with high accuracy. The map is found to be in remarkable agreement with available experimental data. |
| Keywords: | SV40 minichromosome nucleosome mapping of nucleosome mapping of SV40 minichromosome linkers linker lengths sequence analysis for SV40 nucleosome map chromatin nucleosome map of SV40 chromatin structure of SV40 by sequence analysis |
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